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Secondary endpoints included overall survival OS alte behaarte muschi safety. Abstract Background: Understanding how to sequence targeted therapies for metastatic renal cell carcinoma mRCC is important for maximisation of clinical benefit.

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Published by Elsevier B. All rights reserved. Objectives: To prospectively evaluate budapest bordell use of the multikinase inhibitors sorafenib followed by sunitinib So-Su versus sunitinib followed by sorafenib Su-So in patients with mRCC. Trial registration: ClinicalTrials.

Keywords: Renal cell carcinoma; Sequential therapy; Sorafenib; Sunitinib. Outcome measurements and statistical analysis: The primary endpoint was improvement in progression-free survival PFS with Hamburg privat sex versus Su-So, assessed from randomisation to progression or death during second-line therapy.

Associated data ClinicalTrials. These demonstrate that sorafenib followed by sunitinib and vice versa provide similar clinical benefit in mRCC.

Overall, adverse event rates were generally similar between the treatment arms. Background: Understanding how to sequence targeted therapies for metastatic renal cell carcinoma mRCC is important for maximisation of escort 4 ladies benefit.

Intervention: Patients were randomised to sorafenib mg twice daily followed, on progression or intolerable toxicity, by sunitinib 50mg once daily 4 wk on, 2 wk off So-Suor vice versa Su-So.